HPE P42045-B21 ProLiant DL380a Gen11 CTO Server
Overview
The HPE ProLiant DL380a Gen11, identified by part number P42045-B21, is a configure-to-order 2U rack server engineered for accelerator-optimized workloads. This platform is designed for enterprise data centers requiring dense GPU compute capabilities, making it an ideal solution for challenging AI, machine learning, and graphics-intensive applications. It addresses the need for scalable performance in a standard rack-mount footprint. At its core, the server supports dual 4th or 5th Generation Intel Xeon Scalable processors and up to 24 DDR5 DIMMs. This architecture, combined with high-speed PCIe Gen5 I/O slots, delivers the massive bandwidth required for advanced computational tasks. The “a” in the model name signifies its accelerator-optimized design, featuring enhanced cooling to support up to four double-wide or eight single-wide GPUs, ensuring sustained performance for the most demanding workloads. Designed for deployment in standard 19-inch racks, this 2U server provides a dense compute solution. Management is streamlined through the embedded HPE Integrated Lights-Out 6 (iLO 6) ASIC, which offers secure, remote server configuration, monitoring, and updates from anywhere. This comprehensive out-of-band management capability is critical for maintaining operational control over distributed and large-scale environments.
Key Features
- Supports dual 4th or 5th Gen Intel Xeon Scalable CPUs.
- Accommodates up to four double-wide or eight single-wide GPUs.
- Features up to 24 DIMM slots for high-speed DDR5 memory.
- Provides PCIe 5.0 expansion slots for high-throughput I/O.
- Embedded HPE iLO 6 for secure, comprehensive management.


Write a Review